Bridger Ltd
Tuesday, June 16, 2015
MARKETING FLASH INFO


SCIENTIFIC DISCOVERY
THE VITAMIN D, A PREVENTIVE ACTION AGAINST SKIN CANCERS
If ultraviolet radiation (UVR) is the first cause of skin cancer, it is necessary for the vitamin D synthesis. In moderate doses, UVR would even decrease the risk of skin cancers via vitamin D signaling mechanisms.

Indeed, recent studies reveal the protective power of vitamin D in skin cancers but also in other cancers such as colon cancer. The vitamin D produced in the skin would decrease skin tumour formation due to UVR. Moreover, deficit in vitamin D would be associated with a higher risk of diseases and cancers.
THE ROLE OF VITAMIN D RECEPTORS (VDR)
Very present in the skin, VDR play a key role in skin cancer protection. It has been proven that mice population without VDR are more developing more skin cancers. We also know that the number of VDR decreases with ageing. The anticancer role of vitamin D is closely linked with the presence of VDR that act by three mechanisms
  1. Inhibition of tumoral proliferation
  2. Immune system regulation
  3. Stimulation of DNA damage repair
The increase in the number of VDR in the skin would decrease the risk of skin cancer and increase activity of the vitamin D signaling mechanisms.



SCIENTIFIC REFERENCES

(1) Bikle DD, Protective actions of vitamin D in UVB induced skin cancer, Photochem Photobiol Sci. 1808-16,2012
(2) Bikle DD, The vitamin D receptor: a tumor suppressor in skin, Exp Med Bio, 282-302, 2014


THE BEST: BE PROTECTED FROM THE SUN HARMFUL EFFECTS WHILE ENJOYING ITS BENEFITS
The « Daily Defense » Universal Cream from Laboratoires DermEden is the 1st cream to answer to this paradox combining active agents that prevent and treat effects of photoageing (hydrating and anti-ageing active agents, UV protection…) with a « Vitamin D-like » active agent in a day cream.

Indeed, for the first time in cosmetics, this « Vitamin D-like » active agent, the VEDERINE®, helps to compensate vitamin D deficiency of the skin by acting as the calcitriol (active form of vitamin D) and increasing the number of vitamin D receptors (VDR). This increase in the number of VDR would limit the development of skin cancers after UV irradiation.
Laboratoires DermEden Paris
102 avenue des Champs Elysées - 75008 Paris
www.dermedenparis.com
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